تحضير جالكونات الكاربازول الجديدة - مشتقات البايرازولين ودراسة سميتها الخلوية المحتملة لسرطان القولون والرئة والثدي
DOI:
https://doi.org/10.54153/sjpas.2025.v7i2.946الكلمات المفتاحية:
الجالكونات, الكاربازول, البايروزولين, الخلايا السرطانية سرطان القولونالملخص
تم تحضير مركبات جديدة من الجالكونات تحتوي على حلقة الكاربازول من خلال عملية التكثيف بين الالديهايد 9-ethyl-3-carbazolecarboxaldehyde والكيتون 2-acetyl-5-bromothiophene و 3-acetyl-2,5-dimethyl thiophene من خلال طريقة كليزن –شمدت, حيث تمتاز الجالكونات بفعاليته العالية ضد الخلايا السرطان لذلك تم استخدام ثلاث انواع من السرطانات وهي سرطان الرئة A-549: Lung cancer, وسرطان الثديMCF-7: Breast ,Adenocarcinoma وسرطان القولونHCT-116: Colorectal Cancer حيث لاحظنا ان الجالكونات فعالية جدا ضد خلايا سرطان القولون وكانت IC-50 تساوي 4.5 μM للمركب La اما المركب Lb كانت IC-50 تساوي 0.9 μM, كما تم تحضير مشتقات من الجالكونات وهي حلقات خماسية غير متجانسة هي حلقة البايرازولين باستخدام الهيدرازين ومشتقاته, كذلك يمتاز هذه المركبات بفعاليتها ضد الخلايا السرطانية وتم عمل مقارنة بين الجالكون ومشتقاته من هذه الحلقات وتبين ان الجالكونات اكثر فعالية ضد الخلايا السرطانية للقولون حيث كانت IC-50 للمركب La1 تساوي 66.5 μM اما المركب Lb3 تساوي 27.6 μM.
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