Evaluation of some biochemical parameters in the serum of patients with renal failure

Authors

  • Zeina Ahmed Mahdi Department of Chemistry, College of Science, Tikrit University
  • Firas Shawqi Al-Jabouri Faculty of Medicine, Tikrit University
  • Yaser A.M Sulaiman Faculty of Pharmacy, Tikrit University

DOI:

https://doi.org/10.54153/sjpas.2024.v6i1.581

Keywords:

P3H1, GPX1, SAKL, Renal failure, Hemodialysis

Abstract

This study included 70 blood samples of patients with renal failure in the last stage who are undergoing dialysis. the purpose of the current study is to assess some biochemical variables in patients with renal failure and to find out the effect of dialysis on these variables . And to find out the influence of some other factors such as age, gender and body mass index . Variants included measurement of the level of urea , creatinine ,Prolyl 3-hydroxylase1 (P3H1) , solid alpha-Klotho (SAKL) ,. Glutathione peroxidase -1 (GPX1) results: the current study showed an increase in the level of urea and creatinine in both groups of patients compared to the control group and a decrease in the level of both variables in the group of patients after dialysis compared to the pre-dialysis group. It also showed an increase in the level of Glutathione peroxidase - 1 and Prolyl-3-hydroxylase1 for the group of patients before dialysis compared to the control group and there was no difference when comparing the group of patients after dialysis and the control group .it also showed a decrease for the group of patients after dialysis compared to the group of patients before dialysis. There was no significant difference in the level of solid alpha-Klotho when comparing the two groups of patients with the control group, as well as when comparing the two groups of patients before and after dialysis .Age had no effect on urea and creatinine, while it had an effect on the other variables , while BMI had an effect on solid alpha-Klotho only , and gender had no effect on all measured variables

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Published

2024-03-30

How to Cite

Mahdi , Z. A., Al-Jabouri , F. S., & Sulaiman , Y. A. (2024). Evaluation of some biochemical parameters in the serum of patients with renal failure . Samarra Journal of Pure and Applied Science, 6(1), 26–37. https://doi.org/10.54153/sjpas.2024.v6i1.581