Effect of endothelin-1, Vimentin and some biochemical variables on men with type 2 diabetes mellitus, diabetic patients with hypertension, and diabetic patients with renal impairment

Abstract

A comprehensive cross-sectional study was performed to assess the status of endothelin-1, Vimentin, and some biochemical variables. The study included 140 blood samples from men, divided into four groups: Group 1 type 2 diabetes mellitus DM, group 2 type 2 diabetes mellitus and DM +P hypertensive patients, and group 3: type 2 diabetes mellitus and DM patients with - Renal insufficiency + R and the control group (C). Each group included 35 samples, and their ages ranged between (30-70) years. Samples were collected from patients and healthy people from Samarra General Hospital, outpatient clinics and Dalaza Hospital in Tikrit between 20/12/2020 - 20/4/2021. The current study includes measurement of body mass index, determination of serum endothelin-1, vimentin blood protein, fasting glucose-FSG, urea, creatinine, uric acid, and serum Hba1c measurement. The results indicated that the BMI value increased significantly (P≤0.05) in the DM and DM + P groups, while it decreased in the DM + R group compared with the control group, the FSG concentration increased significantly in groups of patients compared to the control group. , the Hba1c concentration increased significantly in the DM and DM + P groups, while DM + R did not show any significant difference compared to the control group, and the results showed that the urea concentration increased significantly in DM + P and DM + R, while DM did not show significant differences Statistic. Compared with the control group, while the creatinine concentration increased significantly in DM + R while DM and DM + P did not show any significant differences compared to the control group, the results also indicated that the uric acid concentration increased significantly in all patient groups compared to the control group. The concentration of nitric oxide decreased significantly in all groups of patients compared to the control group. The results also indicated that the concentration of Endothlen-1 increased significantly in all groups of patients compared to the control group, while the concentration of vimentin did not register any significant differences. In all patient groups compared to the control group. We concluded from the current study that hypertension with diabetes, prediabetes and kidney had a clear effect on biochemical parameters, while diabetes alone had a less pronounced effect.