Review Article: Evaluation and application of click reaction
DOI:
https://doi.org/10.54153/sjpas.2023.v5i4.451Keywords:
Click reaction, Antibacterial, Anticancer, Drugs discoveryAbstract
Click chemistry has been frequently used in the past to speed up lead finding and optimization. In 2001, the term "click chemistry" was coined to describe chemistry designed to swiftly and consistently join tiny molecules to form compounds. Click chemistry, which involves incorporating two highly reactive compounds in a reliable manner without any by-products, is a valuable tool in many fields. One of the most common click reactions, CuAAC, is the azide-alkyne-catalyzed cyclic addition reaction commonly used by chemical biologists, materials science professionals, and polymer chemists. The reaction of CuAAC combines an azide with an alkene to produce a triazole that binds two different molecular entities. The uses of click chemistry in drug discovery have been the subject of this review
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