Aminothiazole, Schiff base: synthesis, characterization and evaluation of their antimicrobial and antioxidant activity
Keywords:Schiff base, Aminothiazole, Antimicrobial, Antioxidant.
The research involves a synthesis of 2-amino-thiazole compounds (sulphanilamide, sulfacetamide, sulphamethoxazole, and 4-amino benzoic acid) with a bromine and potassium cyanide in the presence of glacial acetic acid as a solvent by using microwave irradiation method (S1-S4). Schiff bases were prepared by the reaction of compounds (S1-S4) with Benzaldehyde substitution aldehyde as (3-hydroxy-4-methoxybenzaldehyde, 4-hydroxybenzaldehyde, 4-chlorobenzaldehyde, 4-bromobenzaldehyde). The synthesized compounds were characterization using Fourier transform-infrared (FTIR), mass, proton nuclear magnetic resonance spectroscopy (1H-NMR), and Thin-layer chromatography (TLC). Some of the synthesized compounds were tested for antifungal activity against Candida species and antibacterial activity against isolates of Bacillus Puimilus using Nystatin and Neomycin sulfate as reference standard drugs. The results indicate that the synthesized compounds have the ability to inhibit the growth of the tested fungi and bacteria.
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