Synthesis bis-chalcones, pyrazoline ring and evaluation microbial activity for some of them

Abstract

    The research included the preparation of a number of bis- chalcones compounds m (1-11) starting from acetone with two moles of 2-thiophene carboxaldehyde or substituted benzaldehyde in the presence of sodium hydroxide, and then the corresponding pyrazolines ring m (12-18) were prepared from the reaction of bis- chalcones m (1- 4) With phenyl hydrazine, hydrazine, and thiosemicarbazide. The prepared formulas were confirmed spectroscopically using ultraviolet UV, infrared IR, and Nuclear magnetic resonance 1HNMR and 13CNMR. The biological activity of some of them was tested against Staphylococcus aureus and Candida albicans, at three concentrations (5,7.5,10) mg/ml, in comparison with the antibiotic neomycin sulphate for bacteria and nystatin for fungi at a concentration of 10 mg/ml. The compounds showed high to moderate inhibitory activity and this Indicates promising antibiotics.