Synthesis of some pyrmidin compounds derived from chalcon and evaluation their biological activity

Abstract

In this work, benzothiazole was prepared (AD1) from the reaction of aniline substituted with potassium thiocyanate in presence of bromine. The Diazonum salt was prepared from the reaction of (AD1) with NaNO₂ and HCl then  reacted the mixture with para hydroxyl benzaldehyde to obtained compound (AD2), Chalcon (AD3-8) were obtained from the reaction of compound (AD2) with acetophenone substituted in presence of NaOH, the reaction of compounds (AD3-8)with cyanogondine gives the pyrimidine compounds (AD8-12).In order to show the antibacterial  activity of prepared compounds, it is evaluated against two types of common bacteria (Proteus spp., Escherichia coli,). The result of biological study is compared with standard antibiotic Ciprofloxacin.