Un association of Anti-Mullerian Hormone gene (rs4807216) polymorphism in Polycystic Ovary Syndrome (PCOS) Among Iraqi Women
DOI:
https://doi.org/10.54153/sjpas.2024.v6i2.693Keywords:
polycystic ovary syndrome, PCOS, Anti-Müllerian hormone, AMH hormone, rs4807216 polymorphism.Abstract
The current work aimed to assess the hormonal profile of women with PCOS, including the AMH hormone and the AMH gene (rs4807216) polymorphism. The blood samples were obtained from 60 patients with PCOs who visited Reproductive Medicine Centre of General Hospital of Kirkuk and 30 healthy women. The serum level of LH, FSH, TSH, Estrogen and AMH determined by Enzyme linked immunosorbent assay (ELISA), while Polymerase chain reaction (PCR) was used to genotype the AMH gene (rs4807216). The current results showed a significant increase in LH, TSH, Estrogen, and AMH serum levels in PCOS females as compared to the control female group at P value= 0.05. In contrast, the serum level of FSH was not significantly increased at p value = 0.05. Polymorphism rs4807216was not significantly associated with serum AMH levels in the population study. In conclusion, Women with PCOS have high levels of LH, TSH, Estrogen, and AMH. Therefore, these hormones consider biomarkers for detecting PCOS in Iraqi females.
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