Spectrophotometric Determination of Promethazine Hydrochloride in Pharmaceutical Formulation by Oxidative Coupling
DOI:
https://doi.org/10.54153/sjpas.2021.v3i4.318Keywords:
PromethazineHydrochloride, 4-chloro aniline, Oxidative Coupling, Spectrophotometric Determination.Abstract
A simple, rapid and sensitive spectrophotometric method for determination of trace amounts of Promethazine hydrochloric in aqueous solution is described. The method is based on using the oxidative coupling reaction of promethazine hydrochloride with 4-chloro aniline reagent in acid medium in the presence of N-bromo Succinimide to produce an intense green colour, water soluble, product which exhibit maximum absorbance at 590 nm. Beer's law is obeyed over concentration range of (6-32μg/m1), with a molar absorptivity 7604.856 l/mol.cm, Sandal index of 0.04219μg /cm2 .The average recovery is 100.1185%, relative standard deviation of 1.45826-0.398408% and D.L of 0.41164μg/ml..
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